A <i>SDHC</i> Founder Mutation Causes Paragangliomas (PGLs) in the French Canadians: New Insights on the <i>SDHC</i>-Related PGL

Abstract

We found that 31% of the PGLs in the French Canadian can be explained by the SDHC mutation (c.397C>T, p.[Arg133Ter]). The dominance of the SDHC mutation is unique to the FCs and is most likely due to a French founder effect. SDHC gene analysis should be prioritized in FC patients with PGL.