Concepedia

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TNFα-Induced Mucin 4 Expression Elicits Trastuzumab Resistance in HER2-Positive Breast Cancer

DOI

107

Citations

33

References

2016

Year

María F. Mercogliano, Mara De Martino, Leandro Venturutti, Martín A. Rivas, Cecilia J. Proietti, Gloria Inurrigarro, Isabel Frahm, Daniel H. Allemand, Ernesto Gil Deza, Sandra Ares,
Clinical Cancer Research

Abstract

We identified TNFα-induced MUC4 expression as a novel trastuzumab resistance mechanism. We propose MUC4 expression as a predictive biomarker of trastuzumab efficacy and a guide to combination therapy of TNFα-blocking antibodies with trastuzumab. Clin Cancer Res; 23(3); 636-48. ©2016 AACR.

References

YearCitations

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