<scp>I</scp>ncreased basal ganglia binding of ¹⁸<scp>F‐AV‐1451</scp> in patients with progressive supranuclear palsy

Abstract

We found higher ¹⁸ F-AV-1451 retention in the basal ganglia of PSP patients when compared with healthy elderly controls, but also increases with age in both controls and patients. As a result of the overlap in retention between diagnostic groups and the age-dependent increase present also in controls, ¹⁸ F-AV-1451 PET might not reliably distinguish individual patients with PSP from controls. However, further studies are needed to evaluate whether ¹⁸ F-AV-1451 PET might be useful as a progression marker in clinical PSP trials. © The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.