Interplay between Cytoplasmic and Nuclear Androgen Receptor Splice Variants Mediates Castration Resistance

Abstract

This study suggests important consequences for clinical castration resistance due to simultaneous expression of AR-FL and AR-Vs in patient tumors and suggests that dissecting these interactions should help develop effective strategies to disrupt AR-V signaling. Mol Cancer Res; 15(1); 59-68. ©2016 AACR.