Synthesis and Anti‐influenza Virus Activity of Novel bis(4<i>H</i>‐chromene‐3‐carbonitrile) Derivatives

Abstract

An efficient and convenient method for the synthesis of bis(4 H ‐chromene‐3‐carbonitrile) derivatives by one‐pot, multicomponent reaction of bis‐aldehydes, malononitrile, and dimedone in the presence of a catalytic amount of piperidine is reported. Bis(2‐benzylidene‐1 H ‐indene)‐1,3‐(2 H )‐dione derivatives were obtained as the main products as a result of reaction of the bis(arylidenemalononitriles) with indandione. The anti‐influenza H5N1 virus activities of the newly prepared bis‐chromene derivatives are also investigated.