Nigral and striatal connectivity alterations in asymptomatic <i>LRRK2</i> mutation carriers: A magnetic resonance imaging study

Abstract

Asymptomatic LRRK2 mutation carriers showed functional connectivity changes in striatocortical and nigrocortical circuits compared with noncarriers. These findings support the concept that altered brain connectivity precedes the onset of classical motor features in a genetic form of PD. © 2016 International Parkinson and Movement Disorder Society.