Influence of Dapagliflozin on Glycemic Variations in Patients with Newly Diagnosed Type 2 Diabetes Mellitus

Abstract

<i>Objectives</i>. To observe changes in blood glycemic variations and oxidative stress level before and after dapagliflozin treatment in patients with newly diagnosed T2DM. <i>Methods</i>. This was a randomized, double-blind, placebo-controlled, phase 3 trial. A total of 28 patients with newly diagnosed T2DM with HbA_1c levels of 7.5-10.5% were randomly selected to receive dapagliflozin or placebo treatment for 24 weeks. After baseline data were collected, we analyzed glycemic variations and plasma 8-iso PGF_2<i>α</i> level at baseline and at the endpoint. Primary outcome was the changes of mean amplitude glycemic excursion (MAGE) within groups. <i>Results</i>. After 24-week dapagliflozin therapy, our data showed the significant improvement of MAGE with dapagliflozin therapy (<i>P</i> = 0.010). Compared with control group, patients in dapagliflozin group exhibited reduction in 24-hour MBG (<i>P</i> = 0.026) and lower mean plasma glucose concentrations, especially during periods from 2400 to 0200 and 1300 to 1800 (<i>P</i> < 0.05, resp.). In addition, plasma 8-iso PGF_2<i>α</i> level was notably decreased in the treatment group compared to the control group (<i>P</i> = 0.034). <i>Conclusions.</i> In conclusion, this study shows the ability of dapagliflozin to improve glycemic variations and associate with reduction of oxidative stress in patients with T2DM, which may benefit the cardiovascular system.