Survival and dementia in <scp> <i>GBA</i> </scp> ‐associated Parkinson's disease: <scp>T</scp> he mutation matters

Abstract

Survival is reduced in GBA carriers compared to noncarriers; this seems to be partially independent from the increased risk for early dementia. The risk for dementia is strongly modulated by type of mutation. In the clinical continuum between PD and DLB, patients with GBA mutations seem to localize midway, with carriers of severe mutations closer to DLB than to idiopathic PD. Ann Neurol 2016;80:662-673.