A USEFUL METHOD FOR THE SYNTHESIS OF MACROCYCLIC LACTONE

Abstract

Abstract Long chain hydroxy acids were converted into macrocyclic lactones in high yields by the treatment with 2-chloro-6-methyl-1,3-diphenylpyridinium tetrafluoroborate, 2,6-dimethylpyridine (or 2,4,6-triphenylpyridine) and benzyltriethylammonium chloride. The lactonization reaction was successfully applied to the synthesis of (R) - (+)-ricinelaidic acid lactone, and prostaglandin F2α 1,9- and 1,15-lactones.