Restoration of Hydrogen Sulfide Production in Diabetic Mice Improves Reparative Function of Bone Marrow Cells

Abstract

Decreased CSE-mediated H₂S bioavailability is an underlying source of BMC dysfunction in diabetes mellitus. Our data indicate that H₂S and overexpression of CSE in diabetic BMCs may rescue their dysfunction and open novel avenues for cell-based therapeutics of critical limb ischemia in diabetic patients.