Annals of the Russian academy of medical sciences · 2012 · 21 citations · 0 references
Life SciencesBiochemistryNeuroscienceCellular MetabolismMetabolic RegulationMolecular NeuroscienceGlial Cell BiologyGlial Cell Molecular BiologyGlial Cell SignalingGlial MetabolismNeuroprotectionNicotinamide Adenine Dinucleotide MetabolismAltered Intercellular CommunicationCd38-mediated Nad+ MetabolismNad+ Biosynthetic EnzymesNad+ HomeostasisNad+ Metabolic RegulationNad+ TransportNad+-dependent EnzymesNicotinamide Adenine Dinucleotide (Nad+) Metabolism
The review contains current data on molecular mechanisms which control NAD+ homeostasis in brain cells. It also deals with the role of NAD+-converting enzymes in regulation of functional activity, viability and intercellular communication of neuronal and glial cells. Special attention is paid to involvement of CD38 into regulation of NAD+ levels in brain cells in normal and pathological conditions.