Spinal column chordoma: prognostic significance of clinical variables and<i>T (brachyury</i>) gene SNP rs2305089 for local recurrence and overall survival

Abstract

The ability to achieve a wide en bloc resection at the time of the primary surgery is a critical preoperative consideration, as subtotal resections likely complicate later management. This is the first time the rs2305089 SNP has been implicated in the prognosis of individuals with chordoma, suggesting that screening all patients may be instructive for risk stratification.