Iron(III)‐Catalyzed Peroxide‐Mediated C‐3 Functionalization of Flavones

Abstract

Abstract An iron(III)‐catalyzed C‐3 functionalization of flavones has been achieved using tert ‐butyl peroxybenzoate (TBPB)/potassium persulphate (K 2 S 2 O 8 ) oxidant combinations with a suitable solvent. In the presence of iron(III)/ tert ‐butyl peroxybenzoate/potassium persulphate, the reaction of flavones in cycloalkanes afforded exclusive C‐3 cycloalkylation via C –C coupling, whereas the solvent N , N ‐dialkylformamide provided C‐3 amidation via C –C coupling. Under identical reaction conditions just by switching the solvent to chlorobenzene, C‐3 methylated flavones were obtained where tert ‐butyl peroxybenzoate (TBPB) served as the source of the methyl group. magnified image