Increased Expression of System xc− in Glioblastoma Confers an Altered Metabolic State and Temozolomide Resistance

Abstract

SLC7A11, in addition to redox modulation, appears to be associated with increased cellular metabolism and is a mediator of temozolomide resistance in human glioma, thus making system x_C^- a potential therapeutic target in glioblastoma multiforme. Mol Cancer Res; 14(12); 1229-42. ©2016 AACR.