HPA axis dysregulation, <i>NR3C1</i> polymorphisms and glucocorticoid receptor isoforms imbalance in metabolic syndrome

Abstract

MetS patients exhibited decreased HPA sensitivity to glucocorticoid feedback. Moreover, the BclI polymorphism lower frequency, GRβ overexpression, and IL4 underexpression might underlie the molecular mechanism of glucocorticoid resistance in MetS. Thus, HPA axis dysregulation might contribute to MetS pathogenesis.