Terrecyclic acid A, a new antibiotic from Aspergillus terreus. I. Taxonomy, production, and chemical and biological properties.

Abstract

A new antibiotic, terrecyclic acid A was isolated from the culture filtrate of a new isolate of fungus, identified as Aspergillus terreus. The fermentation yields reached about one gram per liter of the broth. Chemical and biological characterization of the antibiotic revealed that it was a new sesquiterpene having a wide antimicrobial spectrum and antitumor activity.