Pressure controlled drug release in a Zr-cluster-based MOF

Abstract

A robust zirconium-cluster-based metal-organic framework (MOF) ZJU-800 with an excellent drug loading capacity (about 58.80 wt%) has been synthesized. The system shows an adjustable release time of the drug diclofenac sodium from 2 days to 8 days by controlling the degree of compaction between MOF and drug using pressure.