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Palladium-Catalyzed Wacker-Type Oxidation of N-Boc Indoles under Mild Conditions
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2016
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Chemical EngineeringEngineeringNatural SciencesDiversity-oriented SynthesisOrganic ChemistryPalladium-catalyzed Wacker-type OxidationOrganometallic CatalysisCatalysisHigh YieldChemistryMolecular CatalysisSynthetic ChemistryCatalytic Synthesis
Palladium-catalyzed Wacker-type oxidation of <i>N</i>-Boc indoles for the synthesis of 3-oxyindolines has been developed. The palladium-catalyzed Wacker-type oxidation of <i>N</i>-Boc indoles can readily occur in MeCN using H<sub>2</sub>O<sub>2</sub> as oxidant. And 3-oxyindolines were obtained in medium to high yield. Furtherly, the mechanism of palladium-catalyzed Wacker-type oxidation of <i>N</i>-Boc indoles was proposed.