Impairment of Wnt11 function leads to kidney tubular abnormalities and secondary glomerular cystogenesis

Abstract

The Wnt11 signal has roles at the later stages of kidney development, namely in coordinating the development of the tubular system. The C57Bl6 Wnt11 (-/-) mouse generated here provides a model for studying the mechanisms behind tubular anomalies and glomerular cyst formation.