<scp>l</scp>-Isoleucine in a Choline Chloride/Ethylene Glycol Deep Eutectic Solvent: A Reusable Reaction Kit for the Asymmetric Cross-Aldol Carboligation

Abstract

l-Isoleucine is able to catalyze the cross-aldol reaction between cyclohexanone and aromatic aldehydes in a deep eutectic solvent consisting in choline chloride and ethylene glycol, rendering products with high diatereo- and enantioselectivity. This protocol is straightforward and green: the organocatalyst and the reaction medium can be recycled up to five times, allowing the preparation of different substrates with a single load of solvent and catalyst.