The spread of KPC-producing Enterobacteriaceae in Spain: WGS analysis of the emerging high-risk clones of<i>Klebsiella pneumoniae</i>ST11/KPC-2, ST101/KPC-2 and ST512/KPC-3

Abstract

KPC-producing Enterobacteriaceae are increasing in Spain. Most KPC-producing K. pneumoniae isolates belonged to only five clones: ST11 and ST512 caused interregional spread, ST101 caused regional spread and ST1961 and ST678 produced independent hospital outbreaks. ST101/KPC-2 had the highest number of resistance and virulence genes. ST101/KPC-2 and ST512/KPC-3 were recently implicated in the spread of KPC in Italy.