PCR-based detection of <i>Aspergillus fumigatus Cyp51A</i> mutations on bronchoalveolar lavage: a multicentre validation of the AsperGenius assay ^® in 201 patients with haematological disease suspected for invasive aspergillosis

Abstract

The AsperGenius^® assay had a good diagnostic performance on BAL and differentiated WT from Aspergillus fumigatus with RAMs, including in culture-negative BAL samples. Most importantly, detection of RAMs was associated with azole treatment failure.