ACS Applied Materials & Interfaces · 2016 · 56 citations · 26 references
PharmacyMaterials SciencePharmaceuticsBiomaterialsDrug DeliveryNanoparticle Drug DeliveryDrug EncapsulationInorganic NanoparticlesNanomaterials For Drug DeliveryNanomedicineNanoparticle DesignProtein DeliveryCellular Uptake ModulationDrug Delivery NanocarriersLuminescent NanomaterialsNanoparticle Cellular UptakeNanoparticle DeliveryPolymeric Nanoparticle Drug ReleaseProtein Delivery NanoparticlesSolubility
In this report, noncovalent encapsulation of hydrophobic ruthenium(II) polyridyl complexes, Ru(bpy)2dppz(2+) and Ru(phen)2dppz(2+), into apoferritin cavity was achieved with high loading contents by effective prevention of Ru complex-induced protein aggregation, without disruption of protein native architecture. The Ru-loaded luminescent nanocomposites have demonstrated improved water solubility, easy manipulation, reduced cytotoxicity, and enhanced cellular uptake as compared to the nontreated Ru complexes.
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