Selective cytotoxic and cytostatic activity of some phenylpropanoid glycosides

Abstract

The cytotoxic and cytostatic activity of angoroside A, angoroside B, angoroside C, poliumoside and (+)-sylingaresinoi Of-β-glircopyranoside were investigated by the dye exclusion method using 3-[4,5-dimethylthiazol-2-yl-2,5-diphenyltetrazolium bromide (MTT). Caffeic acid-containing phenylpropanoid glycosides were found to exhibit activity against several kinds of cancer cells. However, they did not affect the growth and viability of primary-cultured rat hepatocytes. Study of the structure-activity relationship indicated that ortho-dihydroxy aromatic systems of phenylprapanoid glycosides are necessary for their cytotoxic and cytostatic activities.