Rosuvastatin postconditioning protects isolated hearts against ischemia–reperfusion injury: The role of radical oxygen species, <scp>PI</scp>3K–Akt–<scp>GSK</scp>‐3β pathway, and mitochondrial permeability transition pore

Abstract

Rosuvastatin prevents myocardial ischemia-reperfusion injury by inducing phosphorylation of PI3K-Akt and GSK-3β, preventing oxidative stress and subsequent inhibition of mPTP opening.