Amine Activation: Synthesis of <i>N</i>-(Hetero)arylamides from Isothioureas and Carboxylic Acids

Abstract

A novel method for N-(hetero)arylamide synthesis based on rarely explored amine activation, rather than classical acid activation, is reported. The activated amines are easily prepared using a three-component reaction with commercial reagents. The new method shows a broad scope including challenging amides not (efficiently) accessible via classical protocols.