Concepedia

Publication | Open Access

A coding variant in <i>FTO</i> confers susceptibility to thiopurine-induced leukopenia in East Asian patients with IBD

DOIFull Paper Access

37

Citations

27

References

2016

Year

Han Sang Kim, Jae Hee Cheon, Eun Suk Jung, Joonhee Park, Sowon Aum, Soo Jung Park, Sungho Eun, Jinu Lee, Ulrich Rüther, Giles S.H. Yeo,
Gut

Abstract

The results suggest that the hypomorphic <i>FTO</i> p.A134T variant is associated with thiopurine-induced leukopenia. These results shed light on the novel physiological role of FTO and provide a potential pharmacogenetic biomarker for thiopurine therapy.

References

YearCitations

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