Monomeric eNAMPT in the development of experimental diabetes in mice: a potential target for type 2 diabetes treatment

Abstract

We demonstrate that elevation of monomeric-eNAMPT plays an important role in the pathogenesis of diet-induced diabetes via proinflammatory mechanisms. These data provide proof-of-concept evidence that the eNAMPT-monomer represents a potential therapeutic target for type 2 diabetes.