A one-pot multicomponent facile synthesis of dihydropyrimidin-2(1H)-thione derivatives using triphenylgermane as a catalyst and its binding pattern validation

Abstract

A series of substituted dihydropyrimidin-2(1<italic>H</italic>)-thione derivatives (<bold>1–8</bold>) have been synthesized and docked against enzymes human topoisomerase II alpha (4FM9) and <italic>Helicobacter pylori</italic> urease (1E9Y) for binding mode validation.