A [4 + 1] Cyclative Capture Access to Indolizines via Cobalt(III)-Catalyzed Csp²–H Bond Functionalization

Abstract

A Co(III)-catalyzed [4 + 1] cycloaddition of 2-arylpyridines or 2-alkenylpyridines with aldehydes through Csp(2)-H bond activation has been developed. This protocol provides a facile approach to structurally diverse indolizines including benzoindolizines with a broad range of functional group tolerance.