Pharmacological studies of some blended traditional Chinese medicines on gastric functions. (1) The effects of Oren-gedoku-to (OGT), San'o-syasin-to (SST), Antyu-san (AS) and dai-saiko-to (DST) on ethanol-and aspirin-induced injury of gastric mucosal barrier.

Abstract

We studied the effects of OGT, SST, AS and DST on ethanol- and aspirin-induced reduction of gastric transmucosal potential difference (PD) in rats as an index of gastric mucosal damage, and these effects were compared with those of sucralfate, 16,16-dimethyl-prostaglandin E2 (DMPGE2), cimetidine and proglumide. 1) OGT and SST as well as sucralfate and DMPGE2 significantly inhibited the PD reduction induced by ethanol and aspirin. 2) AS and DST as well as cimetidine significantly inhibited the PD reduction induced by aspirin, but not by ethanol. 3) Proglumide did not influence the PD reduction induced by ethanol and aspirin. 4) OGT alone, like sucralfate and proglumide, showed no influence on the basal PD, while SST, AS and DST, like DMPGE2 and cimetidine, increased the basal PD. These results suggest that OGT, SST, AS and DST protect the gastric mucosal barrier, and this effect of OGT differs from that of SST, AS and DST.