Balance between sodium and calcium currents underlying chronic atrial fibrillation termination: An in silico intersubject variability study

Abstract

Mathematical simulations based on a population of models representing intersubject variability allow the identification of ionic mechanisms underlying rotor dynamics and the definition of new personalized pharmacologic strategies. Our results suggest that the underlying mechanism of the diverging success of I_CaL block as an antiarrhythmic strategy is dependent on the basal availability of sodium and calcium ion channel conductivities.