Radiodiagnosis of peptic ulcer with technetium-99m labeled rabeprazole

Abstract

Rabeprazole, antiulcer drug, was labeled with 99m Tc to obtain an agent for ulcer imaging. The radiochemical yield of 99m Tc-rabeprazole reaches approximately 98.5 ± 0.4%.The optimum conditions are as follows: pH 9, 50 μg of SnCl2·2H2O, 30 min, and 3 mg of the substrate.99m Tc-rabeprazole was stable for 6 h. Intravenous biodistribution studies of 99m Tc-rabeprazole revealed high concentration in the stomach ulcer, reaching about 33.4% of the total injected dose at 30 min post injection. This concentration of 99m Tc-rabeprazole in stomach ulcer makes this agent promising for stomach ulcer imaging.