Comparative pharmacokinetics of <scp>rVIII</scp>‐SingleChain and octocog alfa (Advate^®) in patients with severe haemophilia A

Abstract

rVIII-SingleChain has a favourable pharmacokinetic profile compared with octocog alfa and was well tolerated. The prolonged t1/2 , larger AUC and reduced CL of rVIII-SingleChain may permit longer dosing intervals, thereby improving patient adherence to prophylactic treatment.