Peptidomimetic Targeting of Ca _v β2 Overcomes Dysregulation of the L-Type Calcium Channel Density and Recovers Cardiac Function

Abstract

We have uncovered novel mechanisms modulating LTCC trafficking and life cycle and provide proof of concept for the use of Cavβ2 mimetic peptide as a novel therapeutic tool for the improvement of cardiac conditions correlated with alterations in LTCC levels and function.