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Development of pristane induced mice model for lupus with atherosclerosis and analysis of TLR expression.

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2016

Year

Abstract

We concluded that pristane treated apoE-/- mice exhibited lupus-like phenotype and developed atherosclerosis. The pristane treatment also induced abnormally high expression of TLR2 and TLR4 in the aorta and TLR2, TLR4, TLR7 and TLR9 in the kidney of apoE-/- mice.