Silver nanoparticles/silver chloride (Ag/AgCl) synthesized from Fusarium oxysporum acting against Klebsiella pneumouniae carbapenemase (KPC) and extended spectrum beta-lactamase (ESBL)

Abstract

Silver nanoparticles/silver chloride (Ag/AgCl) biogenically synthesized acted efficiently on all the bacteria that produced beta-lactamases (Extended Spectrum beta-lactamase-ESBL or Klebsiella pneumoniae carbapenemase-KPC). The presence of imipenem (IPM)/Ag/AgCl showed synergism between the IPM antibiotic and Ag/AgCl nanoparticles. The results obtained with E. coli wild type and beta-lactamases producing bacteria reinforced the potentiality of silver nanoparticles on beta-lactamase enzymes, since E. coli is free of any beta-lactamase enzymatic mechanism, and it was not observed any alteration in the IPM zone inhibition with the silver nanoparticles. The study of biogenic nanoparticles efficacy against resistant microorganism is very important due to progressive increase of antibiotic resistant bacteria.