Concepedia

Hexafluoro-2-propanol-Promoted Intermolecular Friedel–Crafts Acylation Reaction

Rakesh H. Vekariya, Jeffrey Aubé

Organic Letters · 2016 · 124 citations · 47 references

DOI

Concepts

Abstract

The intermolecular Friedel-Crafts acylation was carried out in hexafluoro-2-propanol to yield aryl and heteroaryl ketones at room temperature without any additional reagents.

References

47

Friedel-Crafts Chemistry

Royston M. Roberts · Chemical & Engineering News · 1965 · 468 citations

, , +8

Fluorinated Alcohols as Solvents, Cosolvents and Additives in Homogeneous Catalysis

Ivan A. Shuklov, Armin Börner, Natalia V. Dubrovina · Synthesis · 2007 · 416 citations

, , +15

Friedel-Crafts and related reactions

Journal of the Franklin Institute · 1965 · 398 citations

, , +3

Organocatalyzed Asymmetric Friedel–Crafts Reactions

Vincent Terrasson, Renata Marcia de Figueiredo, Jean Marc Campagne · European Journal of Organic Chemistry · 2010 · 284 citations

, , +8

Friedel–Crafts Reaction of Benzyl Fluorides: Selective Activation of CF Bonds as Enabled by Hydrogen Bonding

Pier Alexandre Champagne, Yasmine Benhassine, Justine Desroches et al. · Angewandte Chemie International Edition · 2014 · 238 citations

, , +11