Androgen deprivation causes selective deficits in the biomechanical leg muscle function of men during walking: a prospective case–control study

Abstract

Testosterone deprivation selectively decreases lower-limb muscle function, predominantly affecting muscles that support body weight, accelerate the body forwards during walking, and mediate balance. Future exercise and pro-myogenic interventional studies to mitigate ADT-associated sarcopenia should target these deficits.