Concepedia

Tyrosine triple mutated AAV2-BDNF gene therapy in a rat model of transient IOP elevation.

Tsutomu Igarashi, Koichi Miyake, Maika Kobayashi, Shuhei Kameya, Chiaki Fujimoto, Kenji Nakamoto, Hisatomo Takahashi, Toru Igarashi, Noriko Miyake, Osamu Iijima,

PubMed · 2016 · 28 citations · 47 references

Abstract

These results demonstrate the feasibility and effectiveness of neuroprotective gene therapy using tm-scAAV2-BDNF to protect the inner retina from transiently high intraocular pressure. An in vivo gene therapeutic approach to the clinical management of retinal diseases in conditions such as glaucoma, retinal artery occlusion, hypertensive retinopathy, and diabetic retinopathy thus appears feasible.

References

47

The number of people with glaucoma worldwide in 2010 and 2020

Harry A. Quigley · British Journal of Ophthalmology · 2006 · 7.3K citations · Full text

A BDNF autocrine loop in adult sensory neurons prevents cell death

Ann Acheson, Joanne C. Conover, James P. Fandl et al. · Nature · 1995 · 765 citations

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The neurotrophins BDNF, NT-3, and NGF display distinct patterns of retrograde axonal transport in peripheral and central neurons

Peter S. DiStefano, Beth Friedman, Czeslaw Radziejewski et al. · Neuron · 1992 · 746 citations

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Effects of ocular injury and administration ofbrain-derived neurotrophic factor on survival and regrowth of axotomized retinalganglion cells.

S. Mansour-Robaey, David B. Clarke, Y C Wang et al. · Proceedings of the National Academy of Sciences · 1994 · 727 citations · Full text

Intravitreal injections of neurotrophic factors support the survival of axotomized retinal ganglion cells in adult rats in vivo

Jörg Mey, Solon Thanos · Brain Research · 1993 · 545 citations

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