Concepedia

Insights into significant pathways and gene interaction networks in peripheral blood mononuclear cells for early diagnosis of hepatocellular carcinoma

Jian Jiang, Chao Yu, Zhi Peng Li, Jie Xiao, Hao Zhang, Mei Yuan Chen, Cheng Yi Sun

Journal of Cancer Research and Therapeutics · 2016 · 14 citations · 23 references

Open access

Abstract

Using identified DEGs, significantly changed biological processes such as nucleic acid metabolic process and KEGG pathways such as cytokine-cytokine receptor interaction in PBMCs of HCC patients were identified. In addition, several important hub genes, for example, CUL4A, and interleukin (IL) 8 were also uncovered.

References

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Genetics, Biological Network, Genetic Algorithm +5

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Signaling Pathway, Genetics, Gene Regulation +9

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Phenotypic Variation, Genetics, Genetic Epidemiology +21

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Signal Transduction, Cell Interaction, Cell Motility +7

Signal Transducer and Activator of Transcription 3 Is Required for the Oncogenic Effects of Non–Small-Cell Lung Cancer–Associated Mutations of the Epidermal Growth Factor Receptor

James V. Alvarez, Heidi Greulich, William R. Sellers et al. · Cancer Research · 2006 · 239 citations · Full text