The Prevalence of Founder Mutations among Individuals from Families with Familial Pancreatic Cancer Syndrome

Abstract

The founder mutations in the genes, <i>BRCA1</i>, <i>PALB2</i>, and <i>CHEK2</i>, cause a small percentage of familial pancreatic cancer syndrome in the Polish population. Following confirmation in larger studies, these mutations can be added to the panel of genes to be tested in families with a diagnosis of FPC syndrome.