Concepedia

A dual Cys<scp>LT</scp><sub>1/2</sub> antagonist attenuates allergen‐induced airway responses in subjects with mild allergic asthma

Gail M. Gauvreau, L.‐P. Boulet, J. Mark FitzGerald, Donald W. Cockcroft, Beth E. Davis, Richard Leigh, Masaya Tanaka, J. Fourre, Masaya Tanaka, Toshiya Nabata,

Allergy · 2016 · 22 citations · 43 references

Abstract

Attenuation of EAR, LAR, and airway inflammation is consistent with cysLT<sub>1</sub> blockade. Whether dual cysLT<sub>1/2</sub> antagonism offers additional benefit for treatment of asthma requires further study.

References

43

Indices of airway inflammation in induced sputum: reproducibility and validity of cell and fluid-phase measurements.

Emílio Pizzichini, Márcia Margaret Menezes Pizzichini, Ann Efthimiadis et al. · American Journal of Respiratory and Critical Care Medicine · 1996 · 968 citations

Asthma, Inflammatory Lung Disease, Healthy Subjects +16

Characterization of the human cysteinyl leukotriene CysLT1 receptor

Kevin R. Lynch, Gary P. O’Neill, Qingyun Liu et al. · Nature · 1999 · 967 citations

Inflammation, Cytokine, G Protein-coupled Receptor +5

Characterization of the Human Cysteinyl Leukotriene 2 Receptor

Christopher E. Heise, Brian F. O’Dowd, David J. Figueroa et al. · Journal of Biological Chemistry · 2000 · 660 citations · Full text

Inflammation, Signal Transduction, G Protein-coupled Receptor +7

Montelukast for Chronic Asthma in 6- to 14-Year-Old Children

Barbara Knorr, Jonathan Matz, Jonathan A. Bernstein et al. · JAMA · 1998 · 484 citations

Lung type 2 innate lymphoid cells express cysteinyl leukotriene receptor 1, which regulates TH2 cytokine production

Taylor A. Doherty, Naseem Khorram, Sean Lund et al. · Journal of Allergy and Clinical Immunology · 2013 · 380 citations · Full text

Inflammation, Cytokine, Inflammatory Lung Disease +8