Cyclooxygenase‐2 ( <scp>COX</scp> ‐2) inhibition for prostate cancer chemoprevention: double‐blind randomised study of pre‐prostatectomy celecoxib or placebo

Abstract

Celecoxib had no effect on apoptosis, prostaglandins or AR levels in cancerous or benign prostate tissues. These findings coupled with drug safety concerns should serve to limit interest in these selective drugs as chemopreventive agents.