Publication | Closed Access
Molecular recognition of parallel quadruplex [d-(TTGGGGT)]<sub>4</sub> by mitoxantrone: binding with 1 : 4 stoichiometry leads to telomerase inhibition
14
Citations
28
References
2016
Year
Stacked DimerMolecular RecognitionDna NanotechnologyNucleic Acid ChemistryDnaEngineeringBiochemistryAnti-cancer Drug MitoxantroneNatural SciencesDna AnalysisOligonucleotideMolecular BiologyDna ReplicationCd StudiesChemical BiologyBiomolecular EngineeringDrug Discovery
NMR and CD studies show that anti-cancer drug mitoxantrone (MTX) binds to parallel G-quadruplex DNA [d-(TTGGGGT)<sub>4</sub>] as stacked dimer at grooves leading to increase in thermal stabilization of DNA by ~25 °C and inhibits telomerase with IC<sub>50</sub> = 2 μM.
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