Asymmetric Construction of Highly Functionalized Spirobarbiturate‐Cyclopentenes through Chiral Phosphine‐Catalyzed [3+2] Annulation of Morita–Baylis–Hillman Carbonates with Barbiturate‐Derived Alkenes

Abstract

Abstract A multifunctional chiral phosphine‐catalyzed enantioselective [3+2] annulation of Morita–Baylis–Hillman carbonates with barbiturate‐derived alkenes has been achieved under mild conditions, providing a variety of chiral spirobarbiturate‐cyclopentenes in moderate to excellent yields with moderate to excellent diastereo‐ and enantioselectivities. magnified image