WOUND HEALING ACTIVITY OF LATEX OF CALOTROPIS GIGANTEA

Abstract

The entire wound healing process is a complex series of events that begins at the moment of injury and can continue for months to years. The stages of wound healing are inflammatory phase, proliferation phase, fibroblastic phase and maturation phase. The Latex of Calotropis gigantean (200 mg/kg/day) was evaluated for its wound healing activity in albino rats using excision and incision wound models. Latex treated animals exhibit 83.42 % reduction in wound area when compared to controls which was 76.22 %. The extract treated wounds are found to epithelize faster as compared to controls. Significant (p<0.001) increase in granuloma breaking strength (485±34.64) was observed. The Framycetin sulphate cream (FSC) 1 % w/w was used as standard.