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The Role of FOXP3 in Human Cancers.
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2016
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T-regulatory CellImmunologyPathologyRegulatory T CellsImmune SystemImmunotherapyCancer BiologyTumor BiologyFoxp3 Transcription FactorTumor ImmunityCancer Cell BiologyCancer ResearchMedicineFoxp3 Gene MutationSelf-toleranceAutoimmunityTolerance InductionCancer GeneticsHuman CancersTumor MicroenvironmentCancer ImmunosurveillanceTumor SuppressorOncology
FOXP3 transcription factor can be observed as the main component of the immune system expressed in regulatory T (Treg) cells that regulate hemostasis and self-tolerance. Moreover, the altered expression of FOXP3 was found in autoimmune diseases, benign tumors and carcinomas. Latest reports indicate that the FOXP3 gene mutation can contribute to carcinogenesis, which can be associated with immune response abnormalities. Infiltration of the Treg cells into tumor cells can be associated with prognosis. Understanding the biology of the FOXP3 gene may be crucial in developing new immunotherapeutics.