L‐3‐n‐butylphthalide Rescues Hippocampal Synaptic Failure and Attenuates Neuropathology in Aged<scp>APP</scp>/<scp>PS</scp>1 Mouse Model of Alzheimer's Disease

Abstract

L-NBP may restore synaptic and spine function in aged APP Tg mice through inhibiting Aβ plaques deposition and neuroinflammatory response. Wnt/β-catenin signaling pathway may be involved in L-NBP-related restoration of synaptic function.