Fusion Performance of Low-Dose Recombinant Human Bone Morphogenetic Protein 2 and Bone Marrow-Derived Multipotent Stromal Cells in Biodegradable Scaffolds

Abstract

mPCL/TCP scaffolds loaded with low-dose rhBMP-2 is comparable to autograft bone as a bone graft substitute in this large animal ALIF model. Although BMSCs lagged behind autograft bone and rhBMP-2, evidence of bone ingrowth in this group warrants further investigation. Our results suggest that mPCL/TCP scaffolds loaded with rhBMP-2 or BMSCs may be a viable alternative to conventional cages and autograft bone.